Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immuneresponses
Hapfelmeier S, Lawson M, Slack E, Kirundi J, Stoel M, Heikenwalder M, Cahenzli J, Velykoredko Y, Balmer M, Endt K, Geuking M, Curtiss 3rd R, McCoy K, and Macpherson A.
Science. 2010, in press
 
The unexpected role of lymphotoxin signaling in carcinogenesis: From lymphoid neogenesis to liver and prostate cancer development
Wolf M, Seleznik G, Zeller N and Heikenwalder M.
Oncogene. 2010, in press
 
TAK1 suppresses a NEMO-dependent, but NF-kB independent pathway to liver cancer.
Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, and Luedde T.
Cancer CELL. May 2010, 18;17(5):481-96.
 
Lymphotoxin’s link to carcinogenesis: Friend or Foe?
From lymphoid neogenesis to prostate cancer and hepatocellular carcinoma.
Wolf MJ, Seleznik GM and Heikenwalder M.
Proceedings TNF conference, 2010,  in press.
  
Hepatocyte-specific deletion of Mcl-1 triggers proliferation and hepatocarcinogenesis in mice.
Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer P, Opferman J, Galle P, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H.
Hepatology. 2009 Nov 30; DOI: 10.1002/hep.23479.
 
A lymphotoxin-driven pathway to chronic hepatitis induced liver cancer.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Rolf Graf, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL,  Aguzzi A and Heikenwalder M.
Cancer CELL. 2009 Oct 6;16(4):295-308.

Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.
Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A.
Immunity. 2008 Dec 19;29(6):998-1008.
 
Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.
Heikenwalder M,* Baenziger S,* Johansen P, Schlaepfer E, Hofer U, Miller RC, Diemand S, Honda K, Kundig TM, Aguzzi A, Speck RF.
Blood. 2009 Jan 8;113(2):377-88.
 
Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
Heikenwalder M,* Prinz M,* Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rülicke T, Macpherson AJ, Holländer GA, Nedospasov SA, Aguzzi A.
Am J Pathol. 2008 Jun;172(6):1555-70.
 
Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis.
Hapfelmeier S, Müller AJ, Stecher B, Kaiser P, Barthel M, Endt K, Eberhard M, Robbiani R, Jacobi CA, Heikenwalder M, Kirschning C, Jung S, Stallmach T, Kremer M, Hardt WD.
J Exp Med. 2008 Feb 18;205(2):437-50.
 
Molecular Mechanisms of Prion Pathogenesis.
Aguzzi A, Sigurdson C, Heikenwalder M.
Annu Rev Pathol. 2007 Aug 8.
 
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.
Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, Brück W, Priller J, Prinz M.
Nature Neuroscience 2007 Dec;10(12):1544-53.

Insights into prion strains and neurotoxicity.
Aguzzi A, Heikenwalder M, Polymenidou M.
Nature Reviews in Molecular and Cellular Biology. 2007 Jul;8(7):552-61.  
 
Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-g C-/- mice.
Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF.
PNAS. 2006 Oct 24;103(43):15951-6. Epub 2006 Oct 12.
 
Pathogenesis of prion diseases: current status and future outlook.
Aguzzi A, Heikenwalder M.
Nature Reviews in Microbiology. 2006 Oct;4(10):765-75. 
 
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
Lang KS, Georgiev P, Recher M, Navarini AA, Bergthaler A, Heikenwalder M, Harris NL, Junt T, Odermatt B, Clavien PA, Pircher H, Akira S, Hengartner H, Zinkernagel RM.
J Clin Invest. 2006 Sep;116(9):2456-63.
 
Coincident scrapie infection and nephritis lead to urinary prion excretion.
Heikenwalder M,* Seeger H,* Zeller N,* Kranich J, Schwarz P, Gaspert A, Seifert B, Miele G, Aguzzi A.
Science. 2005 Oct 14;310(5746):324-6.
 
Prions, cytokines, and chemokines: a meeting in lymphoid organs. Aguzzi A, Heikenwalder M.
Immunity. 2005 Feb;22(2):145-54. 
 
Chronic lymphocytic inflammation specifies the organ tropism of prions.
Heikenwalder M, Zeller N, Seeger H, Prinz M, Klöhn PC, Schwarz P, Ruddle N, Weissmann C, Aguzzi A.
Science. 2005 Feb 18;307(5712):1107-10.
 
Progress and problems in the biology, diagnostics, and therapeutics of prion diseases.
Aguzzi A, Heikenwalder M, Miele G.
J Clin Invest. 2004 Jul;114(2):153-60.
 
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.
Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A.
Nature Medicine 2004 Feb;10(2):187-92.
 
Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
Heikenwalder M,* Prinz M,* Junt T, Schwarz P, Glatzel M, Heppner FL, Fu YX, Lipp M, Aguzzi A.
Nature. 2003 Oct 30;425(6961):957-62.
 
Prion diseases: Cannibals and garbage piles.
Aguzzi A, Heikenwalder M.
Nature. 2003 May 8;423(6936):127-9.
 
Prion pathogenesis in the absence of Toll-like receptor signalling.
Prinz M, Heikenwalder M, Schwarz P, Takeda K, Akira S, Aguzzi A.
EMBO Rep. 2003 Feb;4(2):195-9.
 
Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene.
Heikenwalder MF, Koritschoner NP, Pajer P, Chaboissier MC, Kurz SM, Briegel K, Bartunek P, Zenke M.
Gene. 2001 Jul 25;273(1):131-9.

* contributed equally.
 
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